Biomarker Reference · Alt a IgE
Alternaria alternata IgE (Alt a IgE) is a clinical biomarker used in environmental-mould assessment. Alternaria alternata is a ubiquitous outdoor dematiaceous fungus that releases spores prolifically in warm, dry weather. It is measured in 5 laboratory tests on BiomarkersLabs.com.
Alternaria alternata is a ubiquitous outdoor dematiaceous fungus that releases spores prolifically in warm, dry weather. Its allergens are potent triggers of type I hypersensitivity; exposure occurs through inhalation of airborne spores. IgE antibodies to Alternaria bind mast cells and basophils, and upon re-exposure the allergen crosslinks IgE, causing degranulation and release of histamine, leukotrienes, and cytokines that drive acute allergic inflammation.
Alternaria sensitisation is strongly associated with allergic rhinitis and asthma; it is an independent risk factor for asthma severity and has been linked to life-threatening exacerbations. Detection of specific IgE confirms sensitisation and supports clinical correlation with exposure history and symptoms. The degree of sensitisation (class grade) provides some indication of reactivity, though clinical response is not strictly dose-dependent.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
5 tests on BiomarkersLabs.com include this biomarker.
Alternaria alternata IgE reference range in this test: <0.35 kU/L negative; 0.35–0.69 equivocal; ≥0.70 positive.
Alternaria alternata IgE reference range in this test: <0.35 kU/L typically considered negative; 0.35–0.69 equivocal; ≥0.70 positive.
Alternaria alternata IgE reference range in this test: <0.35 kU/L is considered negative; 0.35–0.69 equivocal; ≥0.70 positive.
Alternaria alternata IgE reference range in this test: <0.35 kU/L considered negative; ≥0.35 kU/L positive, with class grades 0–6 reflecting increasing antibody concentration.
Alternaria alternata IgE reference range in this test: <0.35 kU/L is considered negative; ≥0.35 kU/L is positive, with graded severity classes to >100 kU/L.
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