What is Anti-Müllerian Hormone?
Anti-Müllerian hormone is a glycoprotein member of the transforming growth factor-β superfamily, secreted by granulosa cells of growing pre-antral and small antral ovarian follicles. In males it causes regression of the Müllerian ducts during foetal development; in females its principal role is paracrine inhibition of primordial follicle recruitment and modulation of FSH sensitivity in developing follicles. Because AMH is produced by the cohort of small growing follicles, its serum concentration reflects the size of the remaining ovarian follicle pool and declines steadily from the mid-twenties onward, reaching undetectable levels at menopause.