What is Alpha-Amylase?
Alpha-amylase is a hydrolytic enzyme that cleaves dietary starch and glycogen into maltose and dextrins. Circulating total amylase derives from two principal isoenzymes — pancreatic (P-type) from acinar cells and salivary (S-type) from the salivary glands — with minor contributions from the fallopian tubes, lung, and some tumours. It is a small molecule (~55 kDa) that is partly cleared by the kidney, so serum concentrations rise in renal impairment. The plasma half-life is short, on the order of hours, so amylase rises early in acute pancreatic injury and normalises within a few days.