What is Beta Human Chorionic Gonadotrophin?
Human chorionic gonadotrophin is a glycoprotein hormone secreted by the syncytiotrophoblast following implantation of the blastocyst. Its beta subunit is unique to hCG and confers specificity to the assay, distinguishing it from the structurally similar luteinising hormone. Serum hCG doubles approximately every 48–72 hours in early viable intrauterine pregnancy, and the hormone is filtered through the glomerulus into urine, where it can be detected by immunoassay once the concentration exceeds the assay threshold. Qualitative urine assays report a dichotomous result — positive or negative — rather than a numerical concentration.