What is the reference range for Borrelia burgdorferi Immunoglobulin M?

The standard reference range for Borrelia burgdorferi Immunoglobulin M is Negative 1.10 (laboratory-specific cut-offs).. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Borrelia burgdorferi Immunoglobulin M?

Borrelia burgdorferi Immunoglobulin M is measured in 1 test on BiomarkersLabs.com, including B. burgdorferi IgG, IgM by ELISA.

Biomarker Reference · B. burgdorferi IgM

What does the Borrelia burgdorferi Immunoglobulin M test measure?

Borrelia burgdorferi Immunoglobulin M (B. burgdorferi IgM) is a clinical biomarker used in lyme-tick-borne assessment. IgM antibodies appear earlier than IgG, often within the first few weeks of infection, and may decline after several months. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Negative <0.90; equivocal 0.90–1.10; positive >1.10 (laboratory-specific cut-offs).
Units: Index value, Arbitrary units/mL
Measured In: 1 test
Category: —

Functional medicine optimalNegative index value. Transient IgM positivity is expected in early infection; persistent or isolated late IgM often reflects non-specific cross-reactivity rather than true infection.

What is Borrelia burgdorferi Immunoglobulin M?

IgM antibodies appear earlier than IgG, often within the first few weeks of infection, and may decline after several months. They predominantly target the 23 kDa and 41 kDa flagellar antigens. Isolated IgM positivity without IgG, especially outside the first month of symptoms, has a high false-positive rate and should be confirmed by Western blot or repeated with convalescent serology.

Why is Borrelia burgdorferi Immunoglobulin M measured?

IgM is useful in early Lyme disease (within the first month of symptoms) but has limited specificity. Isolated IgM positivity in patients with chronic symptoms (more than one month) is often a false positive and should not be used to diagnose late Lyme disease without confirmatory testing. IgM must always be interpreted alongside IgG, clinical presentation, and exposure history.

Reference ranges

Standard reference: Negative <0.90; equivocal 0.90–1.10; positive >1.10 (laboratory-specific cut-offs).
Functional medicine optimal: Negative index value. Transient IgM positivity is expected in early infection; persistent or isolated late IgM often reflects non-specific cross-reactivity rather than true infection.
Units: Index value, Arbitrary units/mL

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Borrelia burgdorferi Immunoglobulin M

1 test on BiomarkersLabs.com include this biomarker.

BML-LYM-002Comprehensive

B. burgdorferi IgG, IgM by ELISA

Borrelia burgdorferi Immunoglobulin M reference range in this test: Negative <0.90; equivocal 0.90–1.10; positive >1.10 (laboratory-specific cut-offs).

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Borrelia burgdorferi Immunoglobulin GB. burgdorferi IgG1 test

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