What is the reference range for Centromere Protein B Antibody?

The standard reference range for Centromere Protein B Antibody is Negative 40 AU (assay-dependent).. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Centromere Protein B Antibody?

Centromere Protein B Antibody is measured in 1 test on BiomarkersLabs.com, including Centromere B Antibody.

Biomarker Reference · CENP-B Ab

What does the Centromere Protein B Antibody test measure?

Centromere Protein B Antibody (CENP-B Ab) is a clinical biomarker used in autoimmune-inflammation assessment. Centromere protein B is an 80-kDa component of the kinetochore that binds the centromeric alpha-satellite DNA at the primary constriction of mitotic chromosomes. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Negative <20 AU; equivocal 20–40 AU; positive >40 AU (assay-dependent).
Units: Antibody Index, Units (AU)
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNot applicable; this is a qualitative or semi-quantitative result reported as negative, equivocal, or positive.

What is Centromere Protein B Antibody?

Centromere protein B is an 80-kDa component of the kinetochore that binds the centromeric alpha-satellite DNA at the primary constriction of mitotic chromosomes. Anti-centromere antibodies recognise a complex of centromeric proteins (CENP-A, -B, and -C), but CENP-B is the dominant target and the most commonly measured antigen in routine assays. These autoantibodies arise when immune tolerance to nuclear self-antigens breaks down, producing a characteristic punctate nuclear staining pattern on immunofluorescence that reflects the discrete localisation of centromeres within interphase nuclei.

Why is Centromere Protein B Antibody measured?

Anti-centromere antibodies are highly specific for limited cutaneous systemic sclerosis (lcSSc), historically termed CREST syndrome (calcinosis, Raynaud phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia). They are found in approximately 50–90 per cent of lcSSc cases and far less commonly in diffuse cutaneous disease. Positivity predicts a lower risk of severe pulmonary fibrosis compared with anti-topoisomerase (Scl-70) antibodies but an increased risk of isolated pulmonary arterial hypertension. Practitioners use the result to support classification, inform prognosis, and guide surveillance for vascular complications.

Reference ranges

Standard reference: Negative <20 AU; equivocal 20–40 AU; positive >40 AU (assay-dependent).
Functional medicine optimal: Not applicable; this is a qualitative or semi-quantitative result reported as negative, equivocal, or positive.
Units: Antibody Index, Units (AU)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Centromere Protein B Antibody

1 test on BiomarkersLabs.com include this biomarker.

BML-INF-083Comprehensive

Centromere B Antibody

Centromere Protein B Antibody reference range in this test: Negative <20 AU; equivocal 20–40 AU; positive >40 AU (assay-dependent).

Related clinical conditions

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