Biomarker Reference · 16q22 SNPs

What does the Chromosome 16q22 Single Nucleotide Polymorphisms test measure?

Q: What is the reference range for Chromosome 16q22 Single Nucleotide Polymorphisms?

The standard reference range for Chromosome 16q22 Single Nucleotide Polymorphisms is Reported as genotype with associated relative risk; population reference is ancestrally dependent.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Q: Which tests measure Chromosome 16q22 Single Nucleotide Polymorphisms?

Chromosome 16q22 Single Nucleotide Polymorphisms is measured in 1 test on BiomarkersLabs.com, including Atrial Fibrillation Risk Genotype.

Chromosome 16q22 Single Nucleotide Polymorphisms (16q22 SNPs) is a clinical biomarker used in genetic-testing assessment. The 16q22 region contains the ZFHX3 gene, encoding a zinc-finger homeobox transcription factor expressed in atrial myocytes and involved in regulation of cardiac ion channels and structural remodelling. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Reported as genotype with associated relative risk; population reference is ancestrally dependent.
Units: genotype
Measured In: 1 test
Category: Genetic Testing

Functional medicine optimalN/A — results are genotypes, not quantitative levels; risk is expressed as fold-change or percentile relative to population.

What is Chromosome 16q22 Single Nucleotide Polymorphisms?

The 16q22 region contains the ZFHX3 gene, encoding a zinc-finger homeobox transcription factor expressed in atrial myocytes and involved in regulation of cardiac ion channels and structural remodelling. Polymorphisms at rs7193343 and linked SNPs modulate ZFHX3 expression and are independently associated with AF susceptibility, likely through effects on atrial electrical properties and fibrosis pathways.

Why is Chromosome 16q22 Single Nucleotide Polymorphisms measured?

16q22 variants represent a second independent genetic locus contributing to AF risk, with effect sizes slightly smaller than those at 4q25 but additive when both loci carry risk alleles. The combination of multiple risk loci improves discrimination of individuals at the tails of the genetic-risk distribution.

Reference ranges

Standard reference: Reported as genotype with associated relative risk; population reference is ancestrally dependent.
Functional medicine optimal: N/A — results are genotypes, not quantitative levels; risk is expressed as fold-change or percentile relative to population.
Units: genotype

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Chromosome 16q22 Single Nucleotide Polymorphisms

1 test on BiomarkersLabs.com include this biomarker.

BML-GEN-009Comprehensive

Atrial Fibrillation Risk Genotype

Chromosome 16q22 Single Nucleotide Polymorphisms reference range in this test: Reported as genotype with associated relative risk; population reference is ancestrally dependent.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Chromosome 4q25 Single Nucleotide Polymorphisms4q25 SNPs1 test Polygenic Atrial Fibrillation Risk ScorePRS-AF1 test

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