Biomarker Reference · sIgA
Faecal Secretory IgA (sIgA) is a clinical biomarker used in gastrointestinal assessment. Secretory IgA is the predominant immunoglobulin at mucosal surfaces, synthesised by plasma cells in the lamina propria, dimerised, and actively transported across the epithelium. It is measured in 1 laboratory test on BiomarkersLabs.com.
Secretory IgA is the predominant immunoglobulin at mucosal surfaces, synthesised by plasma cells in the lamina propria, dimerised, and actively transported across the epithelium. It binds luminal antigens, pathogens, and toxins, preventing epithelial adhesion and invasion while tolerating commensal flora.
Faecal sIgA reflects mucosal immune competence. Low levels may accompany immune deficiency, chronic stress, malnutrition, or dysbiosis; high levels can indicate an active immune response to enteric infection or dysbiosis. Interpretation is nuanced and must be contextualised with clinical presentation and other markers.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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