Biomarker Reference · Inflammation/Immunology

What does the Gut Inflammation and Immunology Markers (calprotectin, secretory IgA, eosinophil protein X) test measure?

Q: What is the reference range for Gut Inflammation and Immunology Markers (calprotectin, secretory IgA, eosinophil protein X)?

The standard reference range for Gut Inflammation and Immunology Markers (calprotectin, secretory IgA, eosinophil protein X) is Calprotectin: 120 µg/g elevated; secretory IgA and eosinophil protein X reported against method-specific ranges. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Gut Inflammation and Immunology Markers (calprotectin, secretory IgA, eosinophil protein X) (Inflammation/Immunology) is a clinical biomarker used in gastrointestinal assessment. Calprotectin is a neutrophil-derived protein released into the lumen during mucosal inflammation and rises with neutrophilic gut inflammation. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Calprotectin: <50 µg/g normal, 50–120 µg/g borderline, >120 µg/g elevated; secretory IgA and eosinophil protein X reported against method-specific ranges
Units: µg/g, mg/dL
Measured In: 1 test
Category: Gastrointestinal

Functional medicine optimalCalprotectin in the low-normal range is favourable; no validated 'optimal' applies to the secretory-immune markers

What is Gut Inflammation and Immunology Markers (calprotectin, secretory IgA, eosinophil protein X)?

Calprotectin is a neutrophil-derived protein released into the lumen during mucosal inflammation and rises with neutrophilic gut inflammation. Secretory IgA is the dominant mucosal antibody, and eosinophil protein X reflects eosinophil activation.

Why is Gut Inflammation and Immunology Markers (calprotectin, secretory IgA, eosinophil protein X) measured?

Faecal calprotectin is validated for distinguishing inflammatory bowel disease from functional bowel disorders and for guiding the decision to proceed to endoscopy. Secretory IgA and eosinophil protein X are less standardised, and their use to characterise 'gut immune status' is interpretively contested and should not drive diagnosis in isolation.

Reference ranges

Standard reference: Calprotectin: <50 µg/g normal, 50–120 µg/g borderline, >120 µg/g elevated; secretory IgA and eosinophil protein X reported against method-specific ranges
Functional medicine optimal: Calprotectin in the low-normal range is favourable; no validated 'optimal' applies to the secretory-immune markers
Units: µg/g, mg/dL

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Gut Inflammation and Immunology Markers (calprotectin, secretory IgA, eosinophil protein X)

1 test on BiomarkersLabs.com include this biomarker.

BML-GAS-005Comprehensive

GI360 (Comprehensive Molecular Stool Profile)

Gut Inflammation and Immunology Markers (calprotectin, secretory IgA, eosinophil protein X) reference range in this test: Calprotectin: <50 µg/g normal, 50–120 µg/g borderline, >120 µg/g elevated; secretory IgA and eosinophil protein X reported against method-specific ranges

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