What is Immunoglobulin G Antibodies to Food Antigens?
IgG is the most abundant immunoglobulin class in serum, responsible for delayed immune responses to foreign proteins. Food-specific IgG antibodies develop after gastrointestinal exposure to dietary proteins, and their presence reflects immune recognition rather than true allergy. Elevated titres may result from increased intestinal permeability, immune dysregulation, or high-frequency consumption of particular foods, but the clinical significance of IgG reactivity in the absence of IgE-mediated allergy or coeliac disease remains debated.