What does the Oxidative Stress and Antioxidant Status Markers test measure?

Why is Oxidative Stress and Antioxidant Status Markers measured?

The oxidative stress markers in the OAT provide an integrated picture of systemic oxidative burden and antioxidant reserve status — particularly glutathione cycle function — that complements individual antioxidant measurements (serum vitamin C, vitamin E, selenium). Elevated 8-OHdG guides antioxidant support intervention and can serve as a monitoring marker for oxidative stress reduction from dietary, lifestyle, and supplementation interventions over serial OAT assessments. Elevated pyroglutamic acid in a patient with fatigue and immune dysfunction suggests glutathione depletion warranting N-acetylcysteine (NAC), glycine, and glutamine precursor support. In the context of statin therapy, elevated methylglutaric acid and HMG-related metabolites may indicate statin interference with the mevalonate pathway affecting CoQ10 production — guiding CoQ10 supplementation recommendations in symptomatic patients on statins.

Reference ranges

Standard reference

# REVIEWER FLAG: Confirm Mosaic Diagnostics reference ranges for oxidative stress markers — including 8-hydroxy-2-deoxyguanosine (8-OHdG — oxidative DNA damage marker), hydroxymethylglutaric acid (HMG-CoA reductase pathway marker), methylglutaric acid, p-hydroxyphenyllactic acid, and pyroglutamic acid (gamma-glutamyl cycle — marker of glutathione production and cysteine availability). Reference intervals are proprietary to Mosaic's dataset.

Functional medicine optimal

# REVIEWER FLAG: Confirm Mosaic Diagnostics interpretive zones for oxidative stress markers.

Units

mmol/mol creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.