What does the Oestrone test measure?

Why is Oestrone measured?

Oestrone is a secondary oestrogen measurement, used chiefly in specific contexts rather than as a first-line test. It is most relevant in postmenopausal assessment, where it becomes the predominant oestrogen and reflects peripheral aromatisation influenced by adiposity, and in monitoring oestrogen therapy, particularly oral preparations that raise oestrone disproportionately. Oestradiol remains the primary measure of oestrogen status in most clinical contexts, and oestrone is interpreted alongside it rather than instead of it.

Reference ranges

Standard reference

Premenopausal females: approximately 17–200 pg/mL depending on cycle phase; postmenopausal: 7–40 pg/mL; adult males: 10–60 pg/mL # REVIEWER FLAG: Reference intervals are sex-, cycle-, and menopausal-status-specific and assay-dependent; immunoassays perform poorly at low concentrations and LC-MS/MS is preferred — reviewer to confirm against Access Medical Laboratories' assay-specific ranges and methodology.

Functional medicine optimal

Sex-, cycle-, and life-stage-specific; interpreted alongside oestradiol rather than as a standalone target

Units

pg/mL, pmol/L

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.