Biomarker Reference · Prog-M

What does the Progesterone metabolites (pregnanediol-3-glucuronide, others) test measure?

Q: Why is Progesterone metabolites (pregnanediol-3-glucuronide, others) measured?

Progesterone metabolites are used to confirm ovulation, assess luteal sufficiency, and investigate irregular cycles or recurrent pregnancy loss. In functional hormone assessments they complement salivary or serum progesterone, particularly when cycle timing is uncertain.

Q: What is the reference range for Progesterone metabolites (pregnanediol-3-glucuronide, others)?

The standard reference range for Progesterone metabolites (pregnanediol-3-glucuronide, others) is Follicular phase: <1–5 µg/g creatinine; luteal phase: 10–100+ µg/g creatinine; post-menopausal: <2 µg/g creatinine (laboratory-specific).. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Progesterone metabolites (pregnanediol-3-glucuronide, others) (Prog-M) is a clinical biomarker used in female-hormones assessment. Urinary progesterone metabolites — chiefly pregnanediol-3-glucuronide — integrate corpus luteum output across the collection window, making them a useful index of luteal-phase progesterone production without the timing constraints of a single mid-luteal serum sample. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Follicular phase: <1–5 µg/g creatinine; luteal phase: 10–100+ µg/g creatinine; post-menopausal: <2 µg/g creatinine (laboratory-specific).
Units: µg/g creatinine, nmol/mmol creatinine
Measured In: 1 test
Category: Female Hormones

Functional medicine optimalLuteal adequacy is suggested by values well above the follicular-phase range; specific thresholds are assay-dependent.

What is Progesterone metabolites (pregnanediol-3-glucuronide, others)?

Urinary progesterone metabolites — chiefly pregnanediol-3-glucuronide — integrate corpus luteum output across the collection window, making them a useful index of luteal-phase progesterone production without the timing constraints of a single mid-luteal serum sample.

Why is Progesterone metabolites (pregnanediol-3-glucuronide, others) measured?

Progesterone metabolites are used to confirm ovulation, assess luteal sufficiency, and investigate irregular cycles or recurrent pregnancy loss. In functional hormone assessments they complement salivary or serum progesterone, particularly when cycle timing is uncertain.

Reference ranges

Standard reference: Follicular phase: <1–5 µg/g creatinine; luteal phase: 10–100+ µg/g creatinine; post-menopausal: <2 µg/g creatinine (laboratory-specific).
Functional medicine optimal: Luteal adequacy is suggested by values well above the follicular-phase range; specific thresholds are assay-dependent.
Units: µg/g creatinine, nmol/mmol creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Progesterone metabolites (pregnanediol-3-glucuronide, others)

1 test on BiomarkersLabs.com include this biomarker.

BML-HRF-017Comprehensive

Androgens and Progesterones Profile

Progesterone metabolites (pregnanediol-3-glucuronide, others) reference range in this test: Follicular phase: <1–5 µg/g creatinine; luteal phase: 10–100+ µg/g creatinine; post-menopausal: <2 µg/g creatinine (laboratory-specific).

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Testosterone (urinary metabolites)T2 tests Androstenedione (urinary metabolites)A41 test Dehydroepiandrosterone (urinary metabolites)DHEA2 tests Progesterone-to-androgen ratio (derived)Prog:A1 test

Order tests measuring Progesterone metabolites (pregnanediol-3-glucuronide, others) for your patients

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