Description
What is the Cyrex Array 3X Gluten Sensitivity Panel?
The Cyrex Array 3X — Wheat/Gluten Proteome Reactivity and Autoimmunity Panel from BiomarkersLabs.com is an extended version of the Cyrex Array 3, measuring antibody reactivity against an expanded wheat protein proteome and including additional autoimmune cross-reactivity markers — specifically designed for patients with suspected non-celiac gluten sensitivity (NCGS), neurological gluten reactivity, and gluten-associated autoimmunity that falls entirely outside the diagnostic scope of standard celiac serology. Non-celiac gluten sensitivity is a clinical entity defined by GI and extra-intestinal symptoms that occur in response to gluten ingestion, resolve on gluten elimination, and are not explained by celiac disease or wheat allergy. NCGS is estimated to affect 6–10% of the population — substantially more common than celiac disease — but has no established serological diagnostic biomarker in standard clinical practice. The Cyrex Array 3X addresses this diagnostic gap by providing the most comprehensive available antibody-based assessment of immune reactivity to the full wheat and gluten proteome, enabling identification of patients with non-celiac immune reactivity patterns that drive symptom responses to gluten without producing the classic tTG-driven villous atrophy of celiac disease. Specimens processed by Cyrex Laboratories’ CLIA-certified USA laboratory. Results delivered within 7–14 business days. USA only. Licensed practitioners only.
The Array 3X extends the Array 3 antigen coverage with additional wheat proteome fractions and introduces cross-reactivity markers — including antibodies against proteins from other food sources that share structural homology with gluten peptides and may drive immune reactivity in gluten-sensitive patients who have been told their celiac panel is negative. It also includes markers of gluten-related autoimmune cross-reactivity against self-antigens — the mechanism by which gluten-derived peptide immune responses are hypothesised to trigger or perpetuate autoimmune conditions in susceptible individuals. Licensed practitioners only through BiomarkersLabs.com.
What does this panel measure?
All markers of the Cyrex Array 3 (24 wheat protein fractions with IgG and IgA antibodies) plus extended wheat proteome fractions, cross-reactive food antigen antibodies, and autoimmune cross-reactivity markers specific to neurological, thyroid, and other tissue antigens with structural homology to gluten peptides.
Clinical indications
Suspected non-celiac gluten sensitivity undetected by standard celiac testing — patients with reproducible gluten-triggered symptoms and negative tTG IgA, EMA, and Array 3 who require extended proteome assessment for non-classic gluten reactivity patterns.
Neurological symptoms with suspected gluten reactivity — ataxia, peripheral neuropathy, headache, cognitive impairment, and epilepsy with potential gluten-immune aetiology; the Array 3X identifies neurological gluten reactivity markers including extended tTG-6 and cross-reactive neural antigens.
Persistent GI symptoms on gluten-free diet — patients on a strict gluten-free diet who remain symptomatic; cross-reactive food antigens identified by the 3X may explain persistent reactivity to foods considered gluten-free.
Comprehensive wheat and gluten protein reactivity assessment — the most complete available single assessment of immune reactivity to the full wheat and gluten proteome for complex gluten-related clinical presentations.
Functional medicine extended gluten workup — practitioners managing complex autoimmune, neurological, or multi-system presentations with suspected dietary gluten-immune involvement use the Array 3X for the broadest available gluten reactivity characterisation.
Sample type and collection
Sample Type: Blood (serum). No fasting required. Patient must be on a gluten-containing diet. USA only. Cyrex Laboratories CLIA-certified. 7–14 business day turnaround. No New York state restriction.
How to order
Register free at BiomarkersLabs.com. Licensed practitioners only. Pay per test.
Frequently Asked Questions — Celiac and Gluten Panels
What is the difference between celiac disease and non-celiac gluten sensitivity?
Celiac disease is an immune-mediated condition characterised by tTG antibody production, HLA-DQ2/DQ8 genetic susceptibility, and intestinal villous atrophy on biopsy. Non-celiac gluten sensitivity (NCGS) produces gluten-triggered symptoms without tTG antibodies and without intestinal villous atrophy — the immune mechanism is less well characterised and may involve innate rather than adaptive immunity. NCGS is diagnosed clinically by symptom response to gluten elimination after excluding celiac disease and wheat allergy.
When should I order Array 3 (BML-GAS-015) versus Array 3X (BML-GAS-016)?
Order Array 3 when the primary clinical question is extended celiac serology — complex or seronegative celiac, neurological gluten reactivity (gluten ataxia), or dermatitis herpetiformis — in a patient who has tested negative on the standard celiac panel. Order Array 3X when the clinical question extends to non-celiac gluten sensitivity, cross-reactive food antigen reactivity, and gluten-associated autoimmune cross-reactivity in patients with broader multi-system presentations potentially driven by gluten-immune mechanisms.
Do these tests require the patient to be eating gluten?
Yes — all serological gluten and celiac tests, including Arrays 3 and 3X, require the patient to be consuming gluten-containing foods for a minimum of 6 weeks before testing. Antibody levels fall on a gluten-free diet and may normalise completely — testing on a gluten-free diet produces false-negative results that cannot be used to exclude gluten reactivity.
Reviews
There are no reviews yet.