Inhibin B

Description

What is the DUTCH Cycle Mapping Test?

The DUTCH Cycle Mapping Test from BiomarkersLabs.com is the most advanced assessment of female hormonal dynamics across the entire menstrual cycle — capturing the day-to-day fluctuations of oestrogen and progesterone metabolites across a complete cycle through serial dried urine collections at nine time points. Unlike single-point serum measurements that provide a snapshot of hormone levels at one moment in time, the DUTCH Cycle Mapping test reveals the actual hormone pattern as it unfolds across the follicular phase, the ovulatory peak, and the luteal phase — identifying abnormalities in timing, amplitude, and duration that are entirely invisible to single-point testing.

This test is specifically designed for premenopausal women with menstrual irregularity, suspected luteal phase deficiency, recurrent miscarriage, suspected anovulation, or complex hormonal cycle symptoms that have not been explained by standard single-point serum testing. The nine-sample collection protocol maps oestrogen metabolites (oestrone-3-glucuronide) and progesterone metabolites (pregnanediol-3-glucuronide) across the cycle, identifying the exact ovulatory peak timing, the adequacy of the follicular oestrogen rise, the duration and adequacy of the luteal progesterone phase, and the smoothness of hormone transitions. Specimens processed at Precision Analytical’s CLIA-certified laboratory. Results delivered within 10–14 business days. Available in USA only. Licensed practitioners only.

What does the DUTCH Cycle Mapping Test measure?

Oestrone-3-Glucuronide (E1-3G) — urinary oestrogen metabolite measured at nine time points across the cycle, mapping the complete follicular oestrogen rise, ovulatory peak, and luteal oestrogen pattern. Identifies elevated or suppressed oestrogen at specific cycle phases, premature oestrogen decline, and double-peak anomalies.

Pregnanediol-3-Glucuronide (Pd3G) — urinary progesterone metabolite measured at nine time points, mapping the luteal progesterone rise, peak, and decline. Identifies delayed luteal rise, inadequate luteal peak, shortened luteal phase, and luteal phase deficiency patterns invisible to single Day 21 testing.

Ovulation confirmation and timing — the E1-3G peak identifies the ovulatory surge and confirms whether ovulation occurred and when.

Clinical indications

Luteal phase deficiency investigation — single Day 21 progesterone testing can miss luteal phase deficiency if the luteal peak has not yet occurred or has already passed. DUTCH Cycle Mapping provides the complete luteal progesterone curve, identifying true luteal phase deficiency with precision.

Recurrent miscarriage — hormonal cycle pattern investigation — cycle mapping identifies abnormal oestrogen and progesterone patterns that may contribute to implantation failure and early pregnancy loss, providing far more actionable data than single-point testing.

Anovulatory cycle confirmation and ovulation timing — in women with irregular cycles or suspected anovulation, cycle mapping confirms whether ovulation occurred, when it occurred, and whether the luteal phase following ovulation was adequate.

Complex menstrual symptoms unexplained by standard testing — premenstrual syndrome, premenstrual dysphoric disorder, mid-cycle spotting, heavy periods, or hormonally driven mood symptoms that have not been explained by standard panel testing often reveal clear hormonal pattern abnormalities on cycle mapping.

Infertility investigation — hormonal cycle dynamics — for women undergoing fertility investigation, DUTCH Cycle Mapping provides the detailed cycle hormonal picture that guides timing of interventions, progesterone supplementation decisions, and cycle optimisation.

Monitoring progesterone support in fertility treatment — for women on progesterone supplementation during fertility treatment, cycle mapping monitors the adequacy of luteal phase support across the entire luteal phase rather than at a single time point.

Sample type and collection

Dried urine (filter paper card). No fasting required. Nine separate first-morning urine collections are taken at specific days across one complete menstrual cycle — typically Days 6, 8, 10, 12, 13, 14 (ovulatory window), and Days 18, 22, 26 (or equivalent cycle-length-adjusted days). Full instructions and a personalised collection schedule are provided in the DUTCH Cycle Mapping kit. All collections are home-based and mailed to Precision Analytical on completion of the cycle.

Turnaround time

10–14 business days from specimen receipt of the final collection.

Availability

USA only

Compliance

CLIA Certified · HIPAA Compliant

How to order

Register free at BiomarkersLabs.com. Licensed practitioners only. Pay per test — no subscription required. Results are delivered directly and securely to your practitioner portal and are never released directly to patients.