What is the reference range for Anticardiolipin IgG?

The standard reference range for Anticardiolipin IgG is 80 high positive.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Anticardiolipin IgG?

Anticardiolipin IgG is measured in 1 test on BiomarkersLabs.com, including Anticardiolipin Antibodies.

Biomarker Reference · aCL IgG

What does the Anticardiolipin IgG test measure?

Q: Why is Anticardiolipin IgG measured?

IgG aCL is the most clinically relevant isotype for antiphospholipid syndrome, associated with both arterial and venous thrombosis and obstetric complications. Moderate-to-high titres that persist on repeat testing at least twelve weeks apart are one of the laboratory criteria for APS; low-titre or transient positivity carries less thrombotic risk and may reflect infection or other triggers.

Anticardiolipin IgG (aCL IgG) is a clinical biomarker used in cardiovascular assessment. IgG anticardiolipin antibodies are autoantibodies directed against phospholipid-binding proteins, principally beta-2-glycoprotein I, rather than cardiolipin alone. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <20 GPL U/mL negative; 20–80 low-to-moderate positive; >80 high positive.
Units: GPL U/mL, CU
Measured In: 1 test
Category: Cardiovascular

Functional medicine optimalNegative (<20 GPL U/mL). Persistent moderate-to-high positivity (≥40 GPL U/mL on two occasions ≥12 weeks apart) supports a diagnosis of APS in the correct clinical context.

What is Anticardiolipin IgG?

IgG anticardiolipin antibodies are autoantibodies directed against phospholipid-binding proteins, principally beta-2-glycoprotein I, rather than cardiolipin alone. They arise through molecular mimicry or loss of tolerance and persist for weeks to months, making IgG the most specific isotype for chronic thrombotic risk. The epitopes recognised differ between transient infection-associated and persistent pathogenic antibodies.

Why is Anticardiolipin IgG measured?

IgG aCL is the most clinically relevant isotype for antiphospholipid syndrome, associated with both arterial and venous thrombosis and obstetric complications. Moderate-to-high titres that persist on repeat testing at least twelve weeks apart are one of the laboratory criteria for APS; low-titre or transient positivity carries less thrombotic risk and may reflect infection or other triggers.

Reference ranges

Standard reference: <20 GPL U/mL negative; 20–80 low-to-moderate positive; >80 high positive.
Functional medicine optimal: Negative (<20 GPL U/mL). Persistent moderate-to-high positivity (≥40 GPL U/mL on two occasions ≥12 weeks apart) supports a diagnosis of APS in the correct clinical context.
Units: GPL U/mL, CU

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Anticardiolipin IgG

1 test on BiomarkersLabs.com include this biomarker.

BML-CAR-040Comprehensive

Anticardiolipin Antibodies

Anticardiolipin IgG reference range in this test: <20 GPL U/mL negative; 20–80 low-to-moderate positive; >80 high positive.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anticardiolipin IgMaCL IgM1 test Anticardiolipin IgAaCL IgA1 test

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