What is the reference range for ADMA/SDMA Ratio?

The standard reference range for ADMA/SDMA Ratio is Approximately 0.90–1.20; context-dependent and not universally standardised.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure ADMA/SDMA Ratio?

ADMA/SDMA Ratio is measured in 1 test on BiomarkersLabs.com, including ADMA/SDMA Test.

Biomarker Reference · ADMA:SDMA

What does the ADMA/SDMA Ratio test measure?

ADMA/SDMA Ratio (ADMA:SDMA) is a clinical biomarker used in cardiovascular assessment. The ADMA/SDMA ratio reflects the balance between nitric oxide synthase inhibition (ADMA) and renal clearance capacity (SDMA). It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Approximately 0.90–1.20; context-dependent and not universally standardised.
Units: ratio
Measured In: 1 test
Category: Cardiovascular

Functional medicine optimalRatios close to 1.0 are typical; persistently elevated ratios may warrant investigation of oxidative stress, metabolic syndrome, or subclinical endothelial dysfunction.

What is ADMA/SDMA Ratio?

The ADMA/SDMA ratio reflects the balance between nitric oxide synthase inhibition (ADMA) and renal clearance capacity (SDMA). Because both dimethylarginines are produced via similar methylation and proteolysis pathways but cleared by different routes — ADMA mainly enzymatic, SDMA mainly renal — a rising ratio may signal disproportionate ADMA accumulation relative to renal function, suggesting enzymatic dysregulation or oxidative stress.

Why is ADMA/SDMA Ratio measured?

The ratio provides a functional snapshot of endothelial versus renal pathways. An elevated ratio may point to oxidative stress or DDAH impairment even when absolute ADMA is borderline, while a low ratio in the setting of elevated SDMA emphasises renal dysfunction. Interpreting the ratio alongside the absolute concentrations enriches the cardiovascular and metabolic picture.

Reference ranges

Standard reference: Approximately 0.90–1.20; context-dependent and not universally standardised.
Functional medicine optimal: Ratios close to 1.0 are typical; persistently elevated ratios may warrant investigation of oxidative stress, metabolic syndrome, or subclinical endothelial dysfunction.
Units: ratio

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure ADMA/SDMA Ratio

1 test on BiomarkersLabs.com include this biomarker.

BML-CAR-039Comprehensive

ADMA/SDMA Test

ADMA/SDMA Ratio reference range in this test: Approximately 0.90–1.20; context-dependent and not universally standardised.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Asymmetric DimethylarginineADMA1 test Symmetric DimethylarginineSDMA1 test

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