Biomarker Reference · anti-β2GPI IgG
Anti-β2-Glycoprotein-I Antibody IgG (anti-β2GPI IgG) is a clinical biomarker used in cardiovascular assessment. β2-Glycoprotein-I is the principal protein cofactor for antiphospholipid antibodies. It is measured in 1 laboratory test on BiomarkersLabs.com.
β2-Glycoprotein-I is the principal protein cofactor for antiphospholipid antibodies. Antibodies directed against β2GPI itself, rather than the cardiolipin-β2GPI complex, are detected by ELISA and reported in standardised IgG units. These antibodies recognise epitopes on domain I of the protein and are thought to be the pathogenic species driving thrombosis and pregnancy loss.
Anti-β2GPI IgG at moderate-to-high titre is part of the laboratory criteria for antiphospholipid syndrome when confirmed on repeat and is independently associated with thrombosis and adverse pregnancy outcomes. Some evidence suggests anti-β2GPI IgG may be more specific for true APS than anticardiolipin alone.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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