What is the reference range for Apolipoprotein A-1?

The standard reference range for Apolipoprotein A-1 is Approximately 120–180 mg/dL in men, 125–200 mg/dL in women; assay- and age-dependent.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Apolipoprotein A-1?

Apolipoprotein A-1 is measured in 1 test on BiomarkersLabs.com, including Apolipoprotein A-1 (Apo-A) Test.

Biomarker Reference · Apo-A1

What does the Apolipoprotein A-1 test measure?

Apolipoprotein A-1 (Apo-A1) is a clinical biomarker used in cardiovascular assessment. Apolipoprotein A-1 is the principal structural protein of high-density lipoprotein particles, comprising roughly 70% of HDL protein mass. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Approximately 120–180 mg/dL in men, 125–200 mg/dL in women; assay- and age-dependent.
Units: mg/dL, g/L
Measured In: 1 test
Category: Cardiovascular

Functional medicine optimalMany lipidologists favour Apo-A1 >150 mg/dL in men and >160 mg/dL in women as desirable thresholds, though consensus optimal values remain under investigation.

What is Apolipoprotein A-1?

Apolipoprotein A-1 is the principal structural protein of high-density lipoprotein particles, comprising roughly 70% of HDL protein mass. It is synthesised by the liver and intestine and serves as the essential scaffold upon which nascent HDL is assembled. Apo-A1 activates lecithin-cholesterol acyltransferase, the enzyme that esterifies free cholesterol on the HDL surface, enabling reverse cholesterol transport from peripheral tissues to the liver. Its plasma concentration reflects both the number and size distribution of HDL particles, making it a functional measure of HDL-mediated atheroprotection that is independent of cholesterol content.

Why is Apolipoprotein A-1 measured?

Apo-A1 is a quantitative index of HDL particle number and a marker of reverse cholesterol transport capacity. Because HDL cholesterol mass can be misleading when particle size varies, Apo-A1 often provides more precise cardiovascular risk stratification. Epidemiological data link low Apo-A1 to increased coronary risk, independent of LDL cholesterol, and low values are a feature of metabolic syndrome and insulin resistance. The ratio of apolipoprotein B to apolipoprotein A-1 integrates atherogenic and atheroprotective particle burdens into a single metric that performs as well or better than conventional lipid ratios.

Reference ranges

Standard reference: Approximately 120–180 mg/dL in men, 125–200 mg/dL in women; assay- and age-dependent.
Functional medicine optimal: Many lipidologists favour Apo-A1 >150 mg/dL in men and >160 mg/dL in women as desirable thresholds, though consensus optimal values remain under investigation.
Units: mg/dL, g/L

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Apolipoprotein A-1

1 test on BiomarkersLabs.com include this biomarker.

BML-CAR-045Comprehensive

Apolipoprotein A-1 (Apo-A) Test

Apolipoprotein A-1 reference range in this test: Approximately 120–180 mg/dL in men, 125–200 mg/dL in women; assay- and age-dependent.

Related clinical conditions

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