Which tests measure Aquaporin-4 Antibodies IgG?

Aquaporin-4 Antibodies IgG is measured in 1 test on BiomarkersLabs.com, including Add-On: Leaky Brain - Array 20.

Biomarker Reference · AQP4 IgG

What does the Aquaporin-4 Antibodies IgG test measure?

Q: What is the reference range for Aquaporin-4 Antibodies IgG?

The standard reference range for Aquaporin-4 Antibodies IgG is Laboratory-specific functional threshold; note that clinical-grade cell-based AQP4-IgG assays for neuromyelitis optica are performed separately and are not equivalent to Array 20.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Aquaporin-4 Antibodies IgG (AQP4 IgG) is a clinical biomarker used in neurological-mental-health assessment. Aquaporin-4 is a water-channel protein concentrated in astrocyte endfeet at the blood-brain interface and along the glial limitans. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Laboratory-specific functional threshold; note that clinical-grade cell-based AQP4-IgG assays for neuromyelitis optica are performed separately and are not equivalent to Array 20.
Units: Qualitative index
Measured In: 1 test
Category: Neurological

Functional medicine optimalBelow the laboratory-defined elevated-reactivity threshold.

What is Aquaporin-4 Antibodies IgG?

Aquaporin-4 is a water-channel protein concentrated in astrocyte endfeet at the blood-brain interface and along the glial limitans. In neuromyelitis optica spectrum disorder, high-affinity IgG against AQP4 causes complement-mediated astrocyte injury and demyelination; diagnosis requires a validated cell-based assay.

Why is Aquaporin-4 Antibodies IgG measured?

Array 20 includes an antibody screen for aquaporin-4 as one component of a broader barrier-permeability panel. The assay is exploratory and not a substitute for the diagnostic NMOSD test. Positive results require neurology referral and confirmatory testing if central demyelination is suspected.

Reference ranges

Standard reference: Laboratory-specific functional threshold; note that clinical-grade cell-based AQP4-IgG assays for neuromyelitis optica are performed separately and are not equivalent to Array 20.
Functional medicine optimal: Below the laboratory-defined elevated-reactivity threshold.
Units: Qualitative index

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Aquaporin-4 Antibodies IgG

1 test on BiomarkersLabs.com include this biomarker.

BML-CHP-014Comprehensive

Add-On: Leaky Brain - Array 20

Aquaporin-4 Antibodies IgG reference range in this test: Laboratory-specific functional threshold; note that clinical-grade cell-based AQP4-IgG assays for neuromyelitis optica are performed separately and are not equivalent to Array 20.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Blood-Brain Barrier Integrity IgGBBB IgG1 test S100B Antibodies IgGS100B IgG1 test Occludin and Claudin Antibodies IgGTJ-IgG1 test Glial Fibrillary Acidic Protein Antibodies IgGGFAP IgG1 test Myelin Basic Protein Antibodies IgGMBP IgG1 test Neuronal Antigen Panel IgANeuro-IgA1 test

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