What is Detoxification Pathway Gene Panel (Phase I/II, e.g. CYP, GST, NAT variants)?
Hepatic detoxification proceeds through Phase I (e.g. cytochrome P450 enzymes) and Phase II (e.g. glutathione-S-transferase, N-acetyltransferase) reactions that modify and conjugate endogenous and exogenous compounds for excretion. Variants in these genes can alter enzyme activity. The panel reports genotype at selected detoxification-related variants.