What does the Oestradiol test measure?

Why is Oestradiol measured?

In females oestradiol measurement aids investigation of amenorrhoea, menstrual irregularity, infertility, and menopausal status; in males elevated oestradiol may signal obesity-driven aromatisation or oestrogen-secreting tumours, while very low levels can impair bone health. The ratio of oestradiol to testosterone is increasingly recognised as relevant to metabolic and cardiovascular risk in both sexes.

Reference ranges

Standard reference

Adult males approximately 10–40 pg/mL; premenopausal females vary widely with menstrual phase (follicular 20–150, mid-cycle surge 150–400, luteal 60–200 pg/mL); postmenopausal <30 pg/mL; LC-MS platform-specific.

Functional medicine optimal

Optimal oestradiol is context-dependent: premenopausal females require phase-appropriate values; postmenopausal females on hormone therapy often target 40–100 pg/mL; males typically sit in the 20–30 pg/mL range, with marked elevation or suppression prompting further investigation.

Units

pg/mL, pmol/L

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.