What does the Immunoglobulin G to Gliadin test measure?

Why is Immunoglobulin G to Gliadin measured?

IgG-gliadin has largely been supplanted in coeliac serology by more specific markers, yet it appears on expanded food-sensitivity panels as a proxy for gluten exposure and potential non-coeliac gluten sensitivity. Positive results indicate immunological contact with gliadin but do not diagnose coeliac disease, autoimmune enteropathy, or IgE-mediated allergy. They may correlate with patient-reported symptoms when gluten is consumed, although placebo-controlled challenge data remain the reference for establishing causality.

Reference ranges

Standard reference

Laboratory-specific; typically <20 U/mL considered negative, 20–30 equivocal, >30 positive.

Functional medicine optimal

Functional-medicine laboratories often treat lower thresholds (>10–15 U/mL) as clinically meaningful, though these cut-offs lack validation in controlled outcome trials.

Units

U/mL, arbitrary units

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.