Biomarker Reference · Reflex ENA, dsDNA, others
Specific Autoantibodies (Reflex Panel) (Reflex ENA, dsDNA, others) is a clinical biomarker used in autoimmune-inflammation assessment. Reflex testing identifies the molecular target of the ANA reactivity — anti-dsDNA, anti-Sm, anti-RNP, anti-Ro (SSA), anti-La (SSB), anti-Scl-70, anti-centromere, anti-Jo-1, and others. It is measured in 1 laboratory test on BiomarkersLabs.com.
Reflex testing identifies the molecular target of the ANA reactivity — anti-dsDNA, anti-Sm, anti-RNP, anti-Ro (SSA), anti-La (SSB), anti-Scl-70, anti-centromere, anti-Jo-1, and others. These antibodies have distinct disease associations and, in some cases, prognostic and therapeutic implications. Methods include enzyme immunoassay, multiplex bead assays, and line or dot blots.
Specific antibody identity is essential for classification and management — anti-dsDNA and anti-Sm are highly specific for SLE, anti-Ro and anti-La for Sjögren syndrome and neonatal lupus, anti-centromere for limited cutaneous systemic sclerosis, anti-Scl-70 for diffuse systemic sclerosis, and anti-Jo-1 for inflammatory myositis. The reflex cascade ensures that only positive ANA screens proceed to costly specific-antibody testing.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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