What does the Semiquantitative Specific IgE Class Score test measure?

Why is Semiquantitative Specific IgE Class Score measured?

Rising class or concentration raises the statistical probability of clinical reactivity for a given allergen but does not grade reaction severity and does not predict anaphylaxis. The class score is a screening-level output: it frames which allergens merit focused history, component testing, or challenge, and should never be read as a severity index.

Reference ranges

Standard reference

Class 0 negative (<0.35 kU/L); Class 1 low (0.35–0.69); Class 2 moderate (0.70–3.49); Class 3 high (3.50–17.4); Class 4 very high (17.5–49.9); Class 5 (50–99.9); Class 6 extremely high (≥100).

Functional medicine optimal

Class 0 across the panel is the desirable result in an asymptomatic person; any positive class denotes sensitisation only and requires clinical interpretation.

Units

class (0–6)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.