What is the reference range for Tumour Necrosis Factor Alpha Gene Variant?

The standard reference range for Tumour Necrosis Factor Alpha Gene Variant is Wild-type, heterozygous variant, or homozygous variant reported.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Tumour Necrosis Factor Alpha Gene Variant?

Tumour Necrosis Factor Alpha Gene Variant is measured in 1 test on BiomarkersLabs.com, including Add-On CICA Genetics.

Biomarker Reference · TNF-α SNP

What does the Tumour Necrosis Factor Alpha Gene Variant test measure?

Tumour Necrosis Factor Alpha Gene Variant (TNF-α SNP) is a clinical biomarker used in autoimmune-inflammation assessment. Tumour necrosis factor alpha is a master proinflammatory cytokine secreted by macrophages and other immune cells, central to the systemic inflammatory response and implicated in the pathogenesis of rheumatoid arthritis, inflammatory bowel disease, and metabolic disorders. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Wild-type, heterozygous variant, or homozygous variant reported.
Units: genotype
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNot applicable; genotype results do not have a single optimal state, and interpretation is disease- and context-specific.

What is Tumour Necrosis Factor Alpha Gene Variant?

Tumour necrosis factor alpha is a master proinflammatory cytokine secreted by macrophages and other immune cells, central to the systemic inflammatory response and implicated in the pathogenesis of rheumatoid arthritis, inflammatory bowel disease, and metabolic disorders. Polymorphisms in the TNF gene promoter region, notably −308G>A (rs1800629), influence transcriptional activity and circulating TNF-α levels; the A allele is associated with higher constitutive and stimulated TNF-α production.

Why is Tumour Necrosis Factor Alpha Gene Variant measured?

Genotyping TNF-α variants helps stratify patients by their genetic predisposition to heightened inflammatory responses. Those with high-expression alleles may be more susceptible to TNF-driven autoimmune and inflammatory disease and could, in principle, derive greater benefit from anti-TNF biologics, though pharmacogenetic evidence remains incomplete and response is multifactorial.

Reference ranges

Standard reference: Wild-type, heterozygous variant, or homozygous variant reported.
Functional medicine optimal: Not applicable; genotype results do not have a single optimal state, and interpretation is disease- and context-specific.
Units: genotype

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Tumour Necrosis Factor Alpha Gene Variant

1 test on BiomarkersLabs.com include this biomarker.

BML-AUT-008Comprehensive

Add-On CICA Genetics

Tumour Necrosis Factor Alpha Gene Variant reference range in this test: Wild-type, heterozygous variant, or homozygous variant reported.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Interleukin 17F Gene VariantIL17F SNP1 test Transforming Growth Factor Beta 1 Gene VariantTGF-β1 SNP1 test

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