What does the Anti–Double-Stranded DNA Antibody test measure?

Why is Anti–Double-Stranded DNA Antibody measured?

Anti-dsDNA is highly specific for systemic lupus erythematosus (present in approximately 60–70% of patients, lower in those without nephritis) and is one of the immunological criteria in classification systems. Rising titres often herald flare, especially nephritis, making serial measurement useful for monitoring. Transient positivity can occur with infection or medication but sustained elevation in the appropriate clinical context strongly supports SLE.

Reference ranges

Standard reference

Negative (<30 IU/mL, method-dependent).

Functional medicine optimal

Negative. The titre correlates with lupus activity in many—but not all—patients, so trends matter more than absolute values.

Units

IU/mL, Titre

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.