What is the reference range for Extractable Nuclear Antigen Panel?

The standard reference range for Extractable Nuclear Antigen Panel is Negative for all tested specificities.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Extractable Nuclear Antigen Panel?

Extractable Nuclear Antigen Panel is measured in 1 test on BiomarkersLabs.com, including ANA Multiplex, with Reflex to dsDNA.

Biomarker Reference · ENA

What does the Extractable Nuclear Antigen Panel test measure?

Extractable Nuclear Antigen Panel (ENA) is a clinical biomarker used in autoimmune-inflammation assessment. Extractable nuclear antigens are a family of nuclear and cytoplasmic proteins recognised by autoantibodies in systemic rheumatic diseases. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Negative for all tested specificities.
Units: Qualitative or semi-quantitative (negative, borderline, positive), Specific antigens: Smith, RNP, SSA/Ro, SSB/La, Scl-70, Jo-1, centromere
Measured In: 1 test
Category: Autoimmune

Functional medicine optimalNegative. A positive result is interpreted in the clinical and immunological context, not in isolation.

What is Extractable Nuclear Antigen Panel?

Extractable nuclear antigens are a family of nuclear and cytoplasmic proteins recognised by autoantibodies in systemic rheumatic diseases. Each target antigen associates with a distinct clinical phenotype: anti-Smith with SLE, anti-RNP with mixed connective tissue disease, anti-SSA/Ro and anti-SSB/La with Sjögren and neonatal lupus, anti-Scl-70 with diffuse systemic sclerosis, anti-centromere with limited cutaneous systemic sclerosis, and anti-Jo-1 with antisynthetase syndrome.

Why is Extractable Nuclear Antigen Panel measured?

ENA testing refines the differential when ANA is positive, guiding diagnosis and prognostication. Anti-Smith is specific for SLE but insensitive; anti-SSA/Ro carries neonatal lupus and congenital heart block risk in pregnancy; anti-centromere predicts limited scleroderma; anti-Scl-70 signals diffuse scleroderma and lung fibrosis risk; anti-Jo-1 identifies antisynthetase syndrome. These results shape monitoring, counselling, and specialist referral.

Reference ranges

Standard reference: Negative for all tested specificities.
Functional medicine optimal: Negative. A positive result is interpreted in the clinical and immunological context, not in isolation.
Units: Qualitative or semi-quantitative (negative, borderline, positive), Specific antigens: Smith, RNP, SSA/Ro, SSB/La, Scl-70, Jo-1, centromere

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Extractable Nuclear Antigen Panel

1 test on BiomarkersLabs.com include this biomarker.

BML-AUT-010Comprehensive

ANA Multiplex, with Reflex to dsDNA

Extractable Nuclear Antigen Panel reference range in this test: Negative for all tested specificities.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Antinuclear Antibody ScreenANA2 tests Anti–Double-Stranded DNA AntibodyAnti-dsDNA1 test

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