What is the reference range for Apolipoprotein A-1?

The standard reference range for Apolipoprotein A-1 is Approximately 110–180 mg/dL (1.1–1.8 g/L); women run higher than men and intervals are assay-specific.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Apolipoprotein A-1?

Apolipoprotein A-1 is measured in 1 test on BiomarkersLabs.com, including Apolipoprotein A-1 (ApoA-1) Test.

Biomarker Reference · ApoA-1

What does the Apolipoprotein A-1 test measure?

Apolipoprotein A-1 (ApoA-1) is a clinical biomarker used in cardiovascular assessment. Apolipoprotein A-1 is a 243-residue amphipathic protein synthesised chiefly in the liver and small intestine. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Approximately 110–180 mg/dL (1.1–1.8 g/L); women run higher than men and intervals are assay-specific.
Units: mg/dL, g/L
Measured In: 1 test
Category: Cardiovascular

Functional medicine optimalMany lipidology sources regard ApoA-1 above roughly 140 mg/dL in men and 160 mg/dL in women as favourable, though no threshold is a treatment target in its own right.

What is Apolipoprotein A-1?

Apolipoprotein A-1 is a 243-residue amphipathic protein synthesised chiefly in the liver and small intestine. It is the principal structural scaffold of high-density lipoprotein, accounting for roughly two-thirds of HDL protein mass, and it gives the particle its functional identity. Beyond holding the particle together, ApoA-1 activates lecithin-cholesterol acyltransferase (LCAT) to esterify cholesterol within the maturing HDL core and serves as the ligand that docks onto the ABCA1 transporter to accept free cholesterol effluxed from peripheral cells, including lipid-laden macrophages in the arterial wall. In this way it is the molecular engine of reverse cholesterol transport.

Why is Apolipoprotein A-1 measured?

Because each HDL particle carries ApoA-1 but a variable cholesterol cargo, serum ApoA-1 indexes the pool of atheroprotective particles more directly than HDL-cholesterol, which simply weighs the sterol they happen to be carrying. A low ApoA-1 marks diminished reverse-cholesterol-transport capacity and tracks with heightened atherosclerotic risk; its value is greatest when read against apolipoprotein B as the ApoB:ApoA-1 ratio, a single figure that contrasts the atherogenic particle burden with the protective one.

Reference ranges

Standard reference: Approximately 110–180 mg/dL (1.1–1.8 g/L); women run higher than men and intervals are assay-specific.
Functional medicine optimal: Many lipidology sources regard ApoA-1 above roughly 140 mg/dL in men and 160 mg/dL in women as favourable, though no threshold is a treatment target in its own right.
Units: mg/dL, g/L

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Apolipoprotein A-1

1 test on BiomarkersLabs.com include this biomarker.

BML-CAR-036Comprehensive

Apolipoprotein A-1 (ApoA-1) Test

Apolipoprotein A-1 reference range in this test: Approximately 110–180 mg/dL (1.1–1.8 g/L); women run higher than men and intervals are assay-specific.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Apolipoprotein B to Apolipoprotein A-1 RatioApoB:ApoA-11 test

Order tests measuring Apolipoprotein A-1 for your patients

Available exclusively to verified licensed healthcare practitioners. CLIA-certified laboratory results delivered to your secure portal.