What is the reference range for Deamidated Gliadin Peptide IgA Antibody?

The standard reference range for Deamidated Gliadin Peptide IgA Antibody is <20 U/mL negative; ≥20 U/mL positive (laboratory-specific thresholds apply).. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Deamidated Gliadin Peptide IgA Antibody?

Deamidated Gliadin Peptide IgA Antibody is measured in 1 test on BiomarkersLabs.com, including Add-On: Celiac Profile.

Biomarker Reference · DGP-IgA

What does the Deamidated Gliadin Peptide IgA Antibody test measure?

Q: What is Deamidated Gliadin Peptide IgA Antibody?

Gliadin, a prolamin component of wheat gluten, is resistant to complete proteolysis by gastrointestinal enzymes. Tissue transglutaminase deamidates specific glutamine residues in gliadin fragments to glutamic acid, enhancing binding to HLA-DQ2 or HLA-DQ8 and triggering T-cell activation. Antibodies to deamidated gliadin peptides reflect this adaptive immune response and correlate with mucosal inflammation, though less closely than tTG-IgA.

Q: Why is Deamidated Gliadin Peptide IgA Antibody measured?

DGP-IgA adds incremental sensitivity in young children (under two years) and in patients with mild enteropathy or Marsh I/II histology, where tTG-IgA may be weakly positive or negative. It is less specific than tTG-IgA and is not recommended as a standalone first-line test, but its inclusion in a panel can reduce false-negative results in select populations.

Q: Which tests measure Deamidated Gliadin Peptide IgA Antibody?

Deamidated Gliadin Peptide IgA Antibody is measured in 1 test on BiomarkersLabs.com, including Add-On: Celiac Profile.

Deamidated Gliadin Peptide IgA Antibody (DGP-IgA) is a clinical biomarker used in gastrointestinal assessment. Gliadin, a prolamin component of wheat gluten, is resistant to complete proteolysis by gastrointestinal enzymes. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: <20 U/mL negative; ≥20 U/mL positive (laboratory-specific thresholds apply).
Units: U/mL
Measured In: 1 test
Category: Gastrointestinal

Functional medicine optimalUndetectable in the absence of coeliac disease; persistent positivity on a gluten-free diet suggests incomplete adherence or refractory disease.

What is Deamidated Gliadin Peptide IgA Antibody?

Gliadin, a prolamin component of wheat gluten, is resistant to complete proteolysis by gastrointestinal enzymes. Tissue transglutaminase deamidates specific glutamine residues in gliadin fragments to glutamic acid, enhancing binding to HLA-DQ2 or HLA-DQ8 and triggering T-cell activation. Antibodies to deamidated gliadin peptides reflect this adaptive immune response and correlate with mucosal inflammation, though less closely than tTG-IgA.

Why is Deamidated Gliadin Peptide IgA Antibody measured?

DGP-IgA adds incremental sensitivity in young children (under two years) and in patients with mild enteropathy or Marsh I/II histology, where tTG-IgA may be weakly positive or negative. It is less specific than tTG-IgA and is not recommended as a standalone first-line test, but its inclusion in a panel can reduce false-negative results in select populations.

Reference ranges

Standard reference: <20 U/mL negative; ≥20 U/mL positive (laboratory-specific thresholds apply).
Functional medicine optimal: Undetectable in the absence of coeliac disease; persistent positivity on a gluten-free diet suggests incomplete adherence or refractory disease.
Units: U/mL

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Deamidated Gliadin Peptide IgA Antibody

1 test on BiomarkersLabs.com include this biomarker.

BML-GAS-055Comprehensive

Add-On: Celiac Profile

Deamidated Gliadin Peptide IgA Antibody reference range in this test: <20 U/mL negative; ≥20 U/mL positive (laboratory-specific thresholds apply).

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Tissue Transglutaminase IgA AntibodytTG-IgA2 tests Total Immunoglobulin AIgA2 tests Deamidated Gliadin Peptide IgG AntibodyDGP-IgG2 tests

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