Biomarker Reference · IgA
Total Immunoglobulin A (IgA) is a clinical biomarker used in gastrointestinal assessment. Immunoglobulin A is the dominant antibody isotype at mucosal surfaces and in external secretions, where it provides first-line adaptive immune defence. It is measured in 2 laboratory tests on BiomarkersLabs.com.
Immunoglobulin A is the dominant antibody isotype at mucosal surfaces and in external secretions, where it provides first-line adaptive immune defence. Selective IgA deficiency, the most common primary immunodeficiency, affects approximately 1 in 300–700 individuals and is more prevalent in coeliac disease populations. When total IgA is low or absent, IgA-based serological tests for coeliac disease will be falsely negative regardless of disease activity.
Total IgA is measured alongside tTG-IgA to identify IgA deficiency, which would invalidate an IgA-based coeliac screen. In IgA-deficient patients, IgG-based tests—tissue transglutaminase IgG, deamidated gliadin peptide IgG, or endomysial IgG—must be used instead.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
2 tests on BiomarkersLabs.com include this biomarker.
Total Immunoglobulin A reference range in this test: Approximately 70–400 mg/dL (0.7–4.0 g/L), age-dependent.
Total Immunoglobulin A reference range in this test: Approximately 70–400 mg/dL (0.7–4.0 g/L), age-dependent.
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