Biomarker Reference · EMA-IgA
Endomysial IgA Antibody (EMA-IgA) is a clinical biomarker used in gastrointestinal assessment. Endomysial antibodies recognise tissue transglutaminase epitopes displayed on smooth-muscle endomysium, detected by indirect immunofluorescence on monkey oesophagus or human umbilical cord. It is measured in 1 laboratory test on BiomarkersLabs.com.
Endomysial antibodies recognise tissue transglutaminase epitopes displayed on smooth-muscle endomysium, detected by indirect immunofluorescence on monkey oesophagus or human umbilical cord. The target antigen is the same as tTG, so EMA-IgA and tTG-IgA correlate closely, but EMA is operator-dependent and more labour-intensive.
EMA-IgA is highly specific for coeliac disease — approaching 100 per cent in many series — and historically was the reference standard. Today it is used as a confirmatory test when tTG-IgA is weakly positive or the clinical picture is ambiguous, and in paediatric protocols where a very high EMA titre can obviate biopsy in selected cases.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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