Biomarker Reference · DAO
Diamine Oxidase (DAO) is a clinical biomarker used in microbiome-gut assessment. Diamine oxidase is an enzyme produced by enterocytes in the small-intestinal mucosa that degrades histamine and other biogenic amines in the gut lumen and during mucosal absorption. It is measured in 1 laboratory test on BiomarkersLabs.com.
Diamine oxidase is an enzyme produced by enterocytes in the small-intestinal mucosa that degrades histamine and other biogenic amines in the gut lumen and during mucosal absorption. It is released into the circulation in proportion to enterocyte mass and mucosal integrity, making it a functional marker of small-bowel enterocyte health.
Low circulating DAO activity suggests reduced enterocyte mass or function, which can impair histamine degradation and contribute to histamine intolerance — symptoms of flushing, gastrointestinal discomfort, and headache after histamine-rich foods. DAO deficiency is seen with mucosal atrophy, inflammatory enteropathy, and certain medications (NSAIDs, some antibiotics). It is used in the assessment of suspected histamine intolerance and as a marker of small-intestinal mucosal health.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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