What does the Histamine, Urine test measure?

Why is Histamine, Urine measured?

Sanesco includes histamine as a neuroactive amine with relevance to neuroinflammation, sleep-wake regulation, and immune activation. In functional interpretation, elevated urinary histamine points to histamine intolerance, mast cell hyperactivation, gut dysbiosis with histamine-producing bacterial overgrowth, or DAO (diamine oxidase) enzyme insufficiency — and guides dietary histamine reduction and DAO enzyme supplementation. Low histamine is interpreted as reduced histaminergic activation. Dietary high-histamine food intake in the 48 hours before collection is the dominant confounding factor.

Reference ranges

Standard reference

# REVIEWER FLAG: Confirm Sanesco reference range for urinary histamine — values are highly platform-specific and dietary histamine intake significantly elevates results.

Functional medicine optimal

# REVIEWER FLAG: Confirm Sanesco optimal range designation and dietary preparation protocol for histamine specifically.

Units

µg/g creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.