What is the reference range for Plasma Renin Activity?

The standard reference range for Plasma Renin Activity is Approximately 0.2–3.3 ng/mL/h upright (supine lower); assay-, laboratory-, and posture-dependent.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Plasma Renin Activity?

Plasma Renin Activity is measured in 1 test on BiomarkersLabs.com, including Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS.

Biomarker Reference · PRA

What does the Plasma Renin Activity test measure?

Plasma Renin Activity (PRA) is a clinical biomarker used in adrenal-stress assessment. Plasma renin activity measures the rate of angiotensin I generation by circulating renin acting on its endogenous substrate angiotensinogen. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Approximately 0.2–3.3 ng/mL/h upright (supine lower); assay-, laboratory-, and posture-dependent.
Units: ng/mL/h, μg/L/h
Measured In: 1 test
Category: Adrenal

Functional medicine optimalOptimal PRA is contextual; the key is appropriate coupling with aldosterone. Isolated PRA interpretation is less informative than the calculated ratio.

What is Plasma Renin Activity?

Plasma renin activity measures the rate of angiotensin I generation by circulating renin acting on its endogenous substrate angiotensinogen. It is regulated by renal perfusion pressure, sodium delivery to the distal tubule, and sympathetic tone. PRA declines with age and is sensitive to posture, sodium intake, and interfering medications.

Why is Plasma Renin Activity measured?

PRA is the denominator of the ratio and reflects the integrity of the renin–angiotensin–aldosterone axis. Suppressed PRA with elevated aldosterone points to primary aldosteronism; high PRA with elevated aldosterone suggests secondary hyperaldosteronism (renovascular disease, volume depletion); low-renin hypertension without aldosterone excess may reflect a genetic or salt-sensitive phenotype.

Reference ranges

Standard reference: Approximately 0.2–3.3 ng/mL/h upright (supine lower); assay-, laboratory-, and posture-dependent.
Functional medicine optimal: Optimal PRA is contextual; the key is appropriate coupling with aldosterone. Isolated PRA interpretation is less informative than the calculated ratio.
Units: ng/mL/h, μg/L/h

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Plasma Renin Activity

1 test on BiomarkersLabs.com include this biomarker.

BML-ADR-024Comprehensive

Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS

Plasma Renin Activity reference range in this test: Approximately 0.2–3.3 ng/mL/h upright (supine lower); assay-, laboratory-, and posture-dependent.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Plasma Aldosterone ConcentrationPAC1 test Aldosterone/Plasma Renin Activity RatioARR1 test

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