Which tests measure Cortisol, 4-Point Diurnal (Salivary, LC-MS)?

Cortisol, 4-Point Diurnal (Salivary, LC-MS) is measured in 1 test on BiomarkersLabs.com, including Saliva LC-MS Hormones 5 with 4-Point Cortisol Panel.

Biomarker Reference · Cortisol x4

What does the Cortisol, 4-Point Diurnal (Salivary, LC-MS) test measure?

Q: What is the reference range for Cortisol, 4-Point Diurnal (Salivary, LC-MS)?

The standard reference range for Cortisol, 4-Point Diurnal (Salivary, LC-MS) is Method-specific salivary intervals reported at four collection points (morning, noon, evening, night) # REVIEWER FLAG: Four-point salivary cortisol intervals are proprietary and time-point-specific — reviewer to confirm against the laboratory's current intervals and collection times.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Cortisol, 4-Point Diurnal (Salivary, LC-MS) (Cortisol x4) is a clinical biomarker used in adrenal-stress assessment. Cortisol is the principal glucocorticoid, secreted by the adrenal cortex under hypothalamic-pituitary (CRH-ACTH) control with a marked diurnal rhythm peaking after waking and declining to a nocturnal nadir. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Method-specific salivary intervals reported at four collection points (morning, noon, evening, night) # REVIEWER FLAG: Four-point salivary cortisol intervals are proprietary and time-point-specific — reviewer to confirm against the laboratory's current intervals and collection times.
Units: ng/mL, nmol/L
Measured In: 1 test
Category: Adrenal

Functional medicine optimalAn expected morning peak with a progressive decline to a low nighttime value; interpreted as a pattern # REVIEWER FLAG: Pattern-based functional cortisol interpretation is not a mainstream diagnostic standard — reviewer to bound diagnostic claims.

What is Cortisol, 4-Point Diurnal (Salivary, LC-MS)?

Cortisol is the principal glucocorticoid, secreted by the adrenal cortex under hypothalamic-pituitary (CRH-ACTH) control with a marked diurnal rhythm peaking after waking and declining to a nocturnal nadir. Salivary cortisol reflects the free, biologically active fraction. Four samples across the day are collected to construct the diurnal curve — its morning peak, daytime decline, and nighttime nadir.

Why is Cortisol, 4-Point Diurnal (Salivary, LC-MS) measured?

The four-point salivary cortisol curve is used in functional and integrative practice to characterise the shape of the daily cortisol rhythm rather than a single value, assessing patterns attributed to chronic stress, fatigue, and circadian disruption. Late-night salivary cortisol has an established role in screening for Cushing's syndrome, but the functional curve interpretation is distinct and does not replace dynamic endocrine testing for diagnosing adrenal disease.

Reference ranges

Standard reference: Method-specific salivary intervals reported at four collection points (morning, noon, evening, night) # REVIEWER FLAG: Four-point salivary cortisol intervals are proprietary and time-point-specific — reviewer to confirm against the laboratory's current intervals and collection times.
Functional medicine optimal: An expected morning peak with a progressive decline to a low nighttime value; interpreted as a pattern # REVIEWER FLAG: Pattern-based functional cortisol interpretation is not a mainstream diagnostic standard — reviewer to bound diagnostic claims.
Units: ng/mL, nmol/L

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Cortisol, 4-Point Diurnal (Salivary, LC-MS)

1 test on BiomarkersLabs.com include this biomarker.

BML-ADR-010Comprehensive

Saliva LC-MS Hormones 5 with 4-Point Cortisol Panel

Cortisol, 4-Point Diurnal (Salivary, LC-MS) reference range in this test: Method-specific salivary intervals reported at four collection points (morning, noon, evening, night) # REVIEWER FLAG: Four-point salivary cortisol intervals are proprietary and time-point-specific — reviewer to confirm against the laboratory's current intervals and collection times.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Oestradiol (Saliva)E22 tests Progesterone (Saliva)P42 tests Testosterone (Saliva)T2 tests DHEA-S (Salivary, LC-MS)DHEA-S1 test

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