What does the Oestradiol (Saliva) test measure?

Why is Oestradiol (Saliva) measured?

Salivary oestradiol is used in functional and integrative practice to assess bioavailable oestrogen, particularly in the context of menstrual cycle characterisation, the menopausal transition, and hormone therapy monitoring. It does not replace serum oestradiol for diagnosing defined endocrine disorders, and salivary measurement is influenced by collection technique and any topical hormone use.

Reference ranges

Standard reference

Sex-, cycle-, and method-specific salivary intervals # REVIEWER FLAG: Salivary oestradiol intervals are proprietary to the ZRT LC-MS method and are not interchangeable with serum or other salivary assays — reviewer to confirm against the laboratory's current intervals.

Functional medicine optimal

Optimal ranges are context-dependent: pre-menopausal women cycle through follicular and luteal levels, while post-menopausal women on replacement aim for mid-follicular equivalents (approximately 1.5–3 pg/mL in saliva). Functional-medicine targets vary and should be individualised.

Units

pg/mL, pmol/L

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.