Which tests measure Sex Hormone Binding Globulin (dried blood spot)?

Sex Hormone Binding Globulin (dried blood spot) is measured in 1 test on BiomarkersLabs.com, including Blood Spot LCMS Hormones 5 with SHBG.

Biomarker Reference · SHBG

What does the Sex Hormone Binding Globulin (dried blood spot) test measure?

Q: What is the reference range for Sex Hormone Binding Globulin (dried blood spot)?

The standard reference range for Sex Hormone Binding Globulin (dried blood spot) is Sex- and age-specific; adult male approximately 10–60 nmol/L, female 20–120 nmol/L. ZRT platform-specific intervals apply.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Sex Hormone Binding Globulin (dried blood spot) (SHBG) is a clinical biomarker used in male-hormones assessment. SHBG is a hepatic glycoprotein that binds testosterone and oestradiol with high affinity, regulating the bioavailable fraction of sex steroids. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Sex- and age-specific; adult male approximately 10–60 nmol/L, female 20–120 nmol/L. ZRT platform-specific intervals apply.
Units: nmol/L
Measured In: 1 test
Category: Male Hormones

Functional medicine optimalMid-reference range SHBG is generally favoured; very low values suggest insulin resistance and hyperandrogenic states, very high values may reduce bioavailable sex steroids. Optimal thresholds remain individualised.

What is Sex Hormone Binding Globulin (dried blood spot)?

SHBG is a hepatic glycoprotein that binds testosterone and oestradiol with high affinity, regulating the bioavailable fraction of sex steroids. Its synthesis is increased by oestrogens and thyroid hormone and decreased by androgens, insulin, and obesity. SHBG concentration influences the free and bioavailable hormone pools, so measurement alongside total testosterone or oestradiol refines interpretation of androgen and oestrogen status.

Why is Sex Hormone Binding Globulin (dried blood spot) measured?

SHBG is measured to calculate free or bioavailable testosterone, to investigate hyperandrogenism (low SHBG amplifies androgen action) and apparent hypogonadism (high SHBG may reduce bioavailable hormone despite normal total levels), and to assess metabolic syndrome, where low SHBG is a common feature and independent cardiovascular risk marker.

Reference ranges

Standard reference: Sex- and age-specific; adult male approximately 10–60 nmol/L, female 20–120 nmol/L. ZRT platform-specific intervals apply.
Functional medicine optimal: Mid-reference range SHBG is generally favoured; very low values suggest insulin resistance and hyperandrogenic states, very high values may reduce bioavailable sex steroids. Optimal thresholds remain individualised.
Units: nmol/L

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Sex Hormone Binding Globulin (dried blood spot)

1 test on BiomarkersLabs.com include this biomarker.

BML-HRM-015Comprehensive

Blood Spot LCMS Hormones 5 with SHBG

Sex Hormone Binding Globulin (dried blood spot) reference range in this test: Sex- and age-specific; adult male approximately 10–60 nmol/L, female 20–120 nmol/L. ZRT platform-specific intervals apply.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Testosterone (LC-MS dried blood spot)T1 test Estradiol (LC-MS dried blood spot)E21 test Progesterone (LC-MS dried blood spot)P41 test Dehydroepiandrosterone Sulphate (LC-MS dried blood spot)DHEA-S1 test Cortisol (LC-MS dried blood spot)F1 test Free Testosterone (calculated)Free T1 test

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