What does the Superoxide Dismutase 2 Ala16Val Variant test measure?

Why is Superoxide Dismutase 2 Ala16Val Variant measured?

The functional consequences of SOD2 A16V remain contested. Some studies associate the Val allele with increased oxidative damage and risk of cardiometabolic or neurodegenerative disease, others find no effect or paradoxical protection. In the context of a methylation and detoxification panel, the genotype is interpreted as a marker of mitochondrial oxidative-stress handling, though its predictive value is uncertain. It does not alter clinical management in isolation.

Reference ranges

Standard reference

Ala/Ala, Ala/Val, Val/Val

Functional medicine optimal

Not applicable (categorical genotype). Interpretation is exploratory and must be integrated with oxidative-stress biomarkers and clinical phenotype.

Units

genotype

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.