Which tests measure 2-Hydroxyestrone (dried urine, GCMS)?

2-Hydroxyestrone (dried urine, GCMS) is measured in 1 test on BiomarkersLabs.com, including Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites.

Biomarker Reference · 2-OHE1

What does the 2-Hydroxyestrone (dried urine, GCMS) test measure?

Q: What is the reference range for 2-Hydroxyestrone (dried urine, GCMS)?

The standard reference range for 2-Hydroxyestrone (dried urine, GCMS) is Laboratory- and population-specific; interpreted as ratio to 16α-OHE1 and parent oestrogens.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

2-Hydroxyestrone (dried urine, GCMS) (2-OHE1) is a clinical biomarker used in thyroid-endocrine assessment. 2-Hydroxyestrone is formed by CYP1A1/1A2-mediated hydroxylation of estrone at the C-2 position. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Laboratory- and population-specific; interpreted as ratio to 16α-OHE1 and parent oestrogens.
Units: ng/mg creatinine
Measured In: 1 test
Category: Thyroid

Functional medicine optimalHigher 2-OHE1 relative to 16α-OHE1 (ratio >2) is often cited as 'protective,' though this remains an area of ongoing research.

What is 2-Hydroxyestrone (dried urine, GCMS)?

2-Hydroxyestrone is formed by CYP1A1/1A2-mediated hydroxylation of estrone at the C-2 position. It is considered a 'favourable' or less proliferative metabolite because it has weak oestrogenic activity, is rapidly conjugated, and does not form stable DNA adducts.

Why is 2-Hydroxyestrone (dried urine, GCMS) measured?

The 2-hydroxylation pathway is the quantitatively dominant route of oestrogen metabolism. Practitioners in functional and integrative medicine use the 2-OHE1 level and the 2:16α ratio as markers of detoxification capacity and, speculatively, as indicators of breast and endometrial cancer risk, though prospective validation in intervention trials is limited.

Reference ranges

Standard reference: Laboratory- and population-specific; interpreted as ratio to 16α-OHE1 and parent oestrogens.
Functional medicine optimal: Higher 2-OHE1 relative to 16α-OHE1 (ratio >2) is often cited as 'protective,' though this remains an area of ongoing research.
Units: ng/mg creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure 2-Hydroxyestrone (dried urine, GCMS)

1 test on BiomarkersLabs.com include this biomarker.

BML-THY-032Comprehensive

Blood Spot Thyroids + Dried Urine GCMS Estrogen Hormone Metabolites

2-Hydroxyestrone (dried urine, GCMS) reference range in this test: Laboratory- and population-specific; interpreted as ratio to 16α-OHE1 and parent oestrogens.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Thyroid-Stimulating HormoneTSH5 tests Free ThyroxineFT45 tests Free TriiodothyronineFT35 tests Thyroid Peroxidase Antibodies (dried blood spot)TPOAb3 tests Estrone (dried urine, GCMS)E11 test Estradiol (dried urine, GCMS)E21 test Estriol (dried urine, GCMS)E31 test 2-Hydroxyestradiol (dried urine, GCMS)2-OHE21 test

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