Biomarker Reference · Anti-LKM
Anti-Liver-Kidney Microsomal Antibodies (Anti-LKM) is a clinical biomarker used in gastrointestinal assessment. Anti-LKM antibodies target cytochrome P450 enzymes, particularly CYP2D6 (the target of anti-LKM-1), found in the endoplasmic reticulum of hepatocytes and renal tubular cells. It is measured in 1 laboratory test on BiomarkersLabs.com.
Anti-LKM antibodies target cytochrome P450 enzymes, particularly CYP2D6 (the target of anti-LKM-1), found in the endoplasmic reticulum of hepatocytes and renal tubular cells. They define a distinct serological subset of autoimmune hepatitis characterised by the absence of ASMA and ANA.
Anti-LKM-1 is the defining marker of type 2 autoimmune hepatitis, which typically presents in children and young adults and is often more aggressive than type 1. It is mutually exclusive with ASMA and ANA positivity. Anti-LKM antibodies can also appear during interferon therapy for hepatitis C, where they signal drug-induced autoimmune hepatitis. Isolated anti-LKM positivity in a child or young adult with hepatocellular injury warrants urgent specialist assessment.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
1 test on BiomarkersLabs.com include this biomarker.
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