What is the reference range for Antinuclear Antibodies?

The standard reference range for Antinuclear Antibodies is Negative; titre <1:40.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Antinuclear Antibodies?

Antinuclear Antibodies is measured in 1 test on BiomarkersLabs.com, including Autoimmune Liver Disease Panel.

Biomarker Reference · ANA

What does the Antinuclear Antibodies test measure?

Q: What is Antinuclear Antibodies?

Antinuclear antibodies recognise a range of nuclear antigens including double-stranded DNA, histones, ribonucleoproteins, and centromere proteins. They are a hallmark of systemic autoimmune disease but are also found in organ-specific autoimmunity including autoimmune hepatitis. The pattern of immunofluorescence — homogeneous, speckled, nucleolar, or centromere — provides clues to the underlying antigen and associated condition.

Q: Why is Antinuclear Antibodies measured?

ANA is positive in 60–80 per cent of patients with type 1 autoimmune hepatitis, usually at a titre of ≥1:80, and is often seen alongside ASMA. It is less specific than liver-specific antibodies, appearing in systemic lupus erythematosus, Sjögren syndrome, and a range of connective-tissue diseases, as well as at low titre in healthy individuals. In the liver context ANA supports the diagnosis of AIH when combined with hepatocellular injury, elevated IgG, and compatible histology.

Q: Which tests measure Antinuclear Antibodies?

Antinuclear Antibodies is measured in 1 test on BiomarkersLabs.com, including Autoimmune Liver Disease Panel.

Antinuclear Antibodies (ANA) is a clinical biomarker used in gastrointestinal assessment. Antinuclear antibodies recognise a range of nuclear antigens including double-stranded DNA, histones, ribonucleoproteins, and centromere proteins. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Negative; titre <1:40.
Units: titre
Measured In: 1 test
Category: Gastrointestinal

Functional medicine optimalNegative.

What is Antinuclear Antibodies?

Antinuclear antibodies recognise a range of nuclear antigens including double-stranded DNA, histones, ribonucleoproteins, and centromere proteins. They are a hallmark of systemic autoimmune disease but are also found in organ-specific autoimmunity including autoimmune hepatitis. The pattern of immunofluorescence — homogeneous, speckled, nucleolar, or centromere — provides clues to the underlying antigen and associated condition.

Why is Antinuclear Antibodies measured?

ANA is positive in 60–80 per cent of patients with type 1 autoimmune hepatitis, usually at a titre of ≥1:80, and is often seen alongside ASMA. It is less specific than liver-specific antibodies, appearing in systemic lupus erythematosus, Sjögren syndrome, and a range of connective-tissue diseases, as well as at low titre in healthy individuals. In the liver context ANA supports the diagnosis of AIH when combined with hepatocellular injury, elevated IgG, and compatible histology.

Reference ranges

Standard reference: Negative; titre <1:40.
Functional medicine optimal: Negative.
Units: titre

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Antinuclear Antibodies

1 test on BiomarkersLabs.com include this biomarker.

BML-GAS-061Comprehensive

Autoimmune Liver Disease Panel

Antinuclear Antibodies reference range in this test: Negative; titre <1:40.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Anti-Mitochondrial AntibodiesAMA1 test Anti-Smooth Muscle AntibodiesASMA1 test Anti-Liver-Kidney Microsomal AntibodiesAnti-LKM1 test Immunoglobulin GIgG1 test Anti-Soluble Liver Antigen / Liver-Pancreas AntibodiesAnti-SLA/LP1 test

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