What is Arsenic, Blood?
Arsenic exists in multiple chemical forms with different toxicological profiles. Inorganic arsenic (arsenite and arsenate) and their methylated metabolites are toxic and carcinogenic; organic arsenoarsenicals from seafood (arsenobetaine, arsenocholine, arsenosugars) are essentially non-toxic and rapidly cleared in urine. Whole-blood arsenic reflects recent absorption — inorganic arsenic is distributed to tissues within hours and methylated hepatically to monomethylarsonic acid and dimethylarsinic acid, with a blood half-life measured in hours to a few days. Blood arsenic is therefore a snapshot of very recent exposure, and its measurement includes all chemical species unless speciation is requested.