What is the reference range for Cortisol (night/bedtime)?

The standard reference range for Cortisol (night/bedtime) is Salivary cortisol at bedtime typically <1.5–3 nmol/L; Ayumetrix-specific intervals apply.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Cortisol (night/bedtime)?

Cortisol (night/bedtime) is measured in 1 test on BiomarkersLabs.com, including Adrenal Stress Panel.

Biomarker Reference · Cortisol-Nt

What does the Cortisol (night/bedtime) test measure?

Q: What is Cortisol (night/bedtime)?

The night-time or bedtime sample captures the circadian nadir, when cortisol secretion is maximally suppressed under the influence of the suprachiasmatic nucleus and the absence of wakefulness drive. Collection should occur at the patient's usual bedtime, before sleep.

Q: Why is Cortisol (night/bedtime) measured?

Elevated bedtime cortisol disrupts sleep onset and maintenance and is a hallmark of chronic stress, Cushing syndrome, or depression. A persistently high night-time cortisol abolishes the restorative low phase of the rhythm.

Q: Which tests measure Cortisol (night/bedtime)?

Cortisol (night/bedtime) is measured in 1 test on BiomarkersLabs.com, including Adrenal Stress Panel.

Cortisol (night/bedtime) (Cortisol-Nt) is a clinical biomarker used in adrenal-stress assessment. The night-time or bedtime sample captures the circadian nadir, when cortisol secretion is maximally suppressed under the influence of the suprachiasmatic nucleus and the absence of wakefulness drive. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Salivary cortisol at bedtime typically <1.5–3 nmol/L; Ayumetrix-specific intervals apply.
Units: nmol/L, µg/dL
Measured In: 1 test
Category: Adrenal

Functional medicine optimalBedtime cortisol should be near the daily minimum; absolute targets are assay-specific.

What is Cortisol (night/bedtime)?

The night-time or bedtime sample captures the circadian nadir, when cortisol secretion is maximally suppressed under the influence of the suprachiasmatic nucleus and the absence of wakefulness drive. Collection should occur at the patient's usual bedtime, before sleep.

Why is Cortisol (night/bedtime) measured?

Elevated bedtime cortisol disrupts sleep onset and maintenance and is a hallmark of chronic stress, Cushing syndrome, or depression. A persistently high night-time cortisol abolishes the restorative low phase of the rhythm.

Reference ranges

Standard reference: Salivary cortisol at bedtime typically <1.5–3 nmol/L; Ayumetrix-specific intervals apply.
Functional medicine optimal: Bedtime cortisol should be near the daily minimum; absolute targets are assay-specific.
Units: nmol/L, µg/dL

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Cortisol (night/bedtime)

1 test on BiomarkersLabs.com include this biomarker.

BML-ADR-021Comprehensive

Adrenal Stress Panel

Cortisol (night/bedtime) reference range in this test: Salivary cortisol at bedtime typically <1.5–3 nmol/L; Ayumetrix-specific intervals apply.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Cortisol (awakening)Cortisol-Aw2 tests Cortisol (morning, ~30 minutes post-waking)Cortisol-AM5 tests Cortisol (midday)Cortisol-MD4 tests Cortisol (evening)Cortisol-PM5 tests Dehydroepiandrosterone (DHEA, morning)DHEA-AM1 test Cortisol:DHEA ratio (morning)Cortisol:DHEA1 test

Order tests measuring Cortisol (night/bedtime) for your patients

Available exclusively to verified licensed healthcare practitioners. CLIA-certified laboratory results delivered to your secure portal.