What is the reference range for Cortisone (urine, diurnal)?

The standard reference range for Cortisone (urine, diurnal) is Collection-time-specific; parallels cortisol diurnal pattern.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Cortisone (urine, diurnal)?

Cortisone (urine, diurnal) is measured in 1 test on BiomarkersLabs.com, including Dried Urine LCMS Neurotransmitters and Diurnal Hormones I.

Biomarker Reference · Cortisone

What does the Cortisone (urine, diurnal) test measure?

Cortisone (urine, diurnal) (Cortisone) is a clinical biomarker used in neurological-mental-health assessment. Cortisone is the inactive 11-keto metabolite of cortisol, interconverted by 11-beta-hydroxysteroid dehydrogenase isoenzymes. It is measured in 1 laboratory test on BiomarkersLabs.com.

Reference Range: Collection-time-specific; parallels cortisol diurnal pattern.
Units: ng/mg creatinine, μg/g creatinine
Measured In: 1 test
Category: Neurological

Functional medicine optimalNo consensus; functional interpretation is laboratory-specific.

What is Cortisone (urine, diurnal)?

Cortisone is the inactive 11-keto metabolite of cortisol, interconverted by 11-beta-hydroxysteroid dehydrogenase isoenzymes. It is produced locally in tissues to buffer cortisol activity and is reconverted to cortisol in target tissues. Urine cortisone reflects both adrenal secretion and peripheral cortisol metabolism.

Why is Cortisone (urine, diurnal) measured?

Measuring both cortisol and cortisone in urine provides insight into 11-beta-HSD activity and the balance between active and inactive glucocorticoid forms. Altered cortisol-to-cortisone ratios may reflect enzyme deficiency or altered local tissue glucocorticoid metabolism. This is an emerging functional biomarker; standard clinical practice measures cortisol alone.

Reference ranges

Standard reference: Collection-time-specific; parallels cortisol diurnal pattern.
Functional medicine optimal: No consensus; functional interpretation is laboratory-specific.
Units: ng/mg creatinine, μg/g creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Cortisone (urine, diurnal)

1 test on BiomarkersLabs.com include this biomarker.

BML-NMH-007Comprehensive

Dried Urine LCMS Neurotransmitters and Diurnal Hormones I

Cortisone (urine, diurnal) reference range in this test: Collection-time-specific; parallels cortisol diurnal pattern.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

DopamineDA4 tests NorepinephrineNE3 tests EpinephrineEpi3 tests Serotonin5-HT4 tests Gamma-Aminobutyric AcidGABA4 tests GlutamateGlu4 tests Cortisol (urine, diurnal)Cortisol1 test Melatonin (urine, as 6-sulfatoxymelatonin or direct)Melatonin1 test

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