What is the reference range for Epinephrine?

The standard reference range for Epinephrine is Laboratory-specific; typically 2–20 µg/g creatinine in random urine.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Epinephrine?

Epinephrine is measured in 3 tests on BiomarkersLabs.com, including Comprehensive Neurotransmitter Add-On - Random, Comprehensive Neurotransmitter Profile - 24 hr, Dried Urine LCMS Neurotransmitters and Diurnal Hormones I.

Biomarker Reference · Epi

What does the Epinephrine test measure?

Epinephrine (Epi) is a clinical biomarker used in neurological-mental-health assessment. Epinephrine is synthesised from norepinephrine by phenylethanolamine N-methyltransferase, an enzyme almost exclusively expressed in the adrenal medulla. It is measured in 3 laboratory tests on BiomarkersLabs.com.

Reference Range: Laboratory-specific; typically 2–20 µg/g creatinine in random urine.
Units: µg/g creatinine, nmol/mmol creatinine, µg/24 hr, nmol/24 hr, ng/mg creatinine, μg/g creatinine
Measured In: 3 tests
Category: Neurological

Functional medicine optimalOptimal ranges for mental-health or functional assessment are not established; urinary epinephrine serves primarily as a screening tool for catecholamine-excess states.

What is Epinephrine?

Epinephrine is synthesised from norepinephrine by phenylethanolamine N-methyltransferase, an enzyme almost exclusively expressed in the adrenal medulla. It amplifies the acute stress response, mobilises glucose and fatty acids, and modulates arousal and memory consolidation. Urine epinephrine reflects adrenomedullary secretion rather than neuronal release, with its metabolite metanephrine used in phaeochromocytoma work-up.

Why is Epinephrine measured?

Urine epinephrine is a marker of adrenal-mediated acute stress and can be elevated in anxiety, panic disorder, or catecholamine-secreting tumours. Low values may reflect blunted stress reactivity or autonomic dysfunction. It is read alongside norepinephrine and cortisol in functional stress assessment.

Reference ranges

Standard reference: Laboratory-specific; typically 2–20 µg/g creatinine in random urine.
Functional medicine optimal: Optimal ranges for mental-health or functional assessment are not established; urinary epinephrine serves primarily as a screening tool for catecholamine-excess states.
Units: µg/g creatinine, nmol/mmol creatinine, µg/24 hr, nmol/24 hr, ng/mg creatinine, μg/g creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Epinephrine

3 tests on BiomarkersLabs.com include this biomarker.

BML-NMH-003Comprehensive

Comprehensive Neurotransmitter Add-On - Random

Epinephrine reference range in this test: Laboratory-specific; typically 2–20 µg/g creatinine in random urine.

BML-NMH-004Comprehensive

Comprehensive Neurotransmitter Profile - 24 hr

Epinephrine reference range in this test: Laboratory-specific; approximately 2–24 µg/24 hr in adults.

BML-NMH-007Comprehensive

Dried Urine LCMS Neurotransmitters and Diurnal Hormones I

Epinephrine reference range in this test: Method- and laboratory-specific.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Serotonin5-HT4 tests DopamineDA4 tests NorepinephrineNE3 tests Gamma-Aminobutyric AcidGABA4 tests GlutamateGlu4 tests GlycineGly3 tests HistamineHis3 tests Dopamine to Norepinephrine RatioDA:NE1 test

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