Biomarker Reference · GABA
Gamma-Aminobutyric Acid (GABA) is a clinical biomarker used in neurological-mental-health assessment. GABA is the principal inhibitory neurotransmitter in the mammalian central nervous system, synthesised from glutamate by glutamic acid decarboxylase. It is measured in 4 laboratory tests on BiomarkersLabs.com.
GABA is the principal inhibitory neurotransmitter in the mammalian central nervous system, synthesised from glutamate by glutamic acid decarboxylase. It is also produced peripherally in the enteric nervous system, pancreatic beta cells, and immune cells. GABA does not cross the blood–brain barrier; urine GABA therefore reflects peripheral metabolism, and its relationship to central GABAergic tone is indirect and contested.
Urine GABA is measured in functional neurotransmitter panels to explore anxiety, insomnia, and seizure disorders, but the evidence linking peripheral GABA to central nervous system GABA activity is limited. Interpretation is exploratory; clinical decisions about GABA-related disorders rely on history, neurophysiology, and brain imaging rather than urine assays.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
4 tests on BiomarkersLabs.com include this biomarker.
Gamma-Aminobutyric Acid reference range in this test: Laboratory-specific; typically 1–5 µg/g creatinine in random urine.
Gamma-Aminobutyric Acid reference range in this test: Laboratory-specific; typically 0.5–5.0 µg/24 hr in adults.
Gamma-Aminobutyric Acid reference range in this test: Laboratory-specific; typically 1–5 µg/g creatinine for random urine.
Gamma-Aminobutyric Acid reference range in this test: Method-specific; dried-urine GABA is not a standard clinical assay.
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