What is the reference range for Norepinephrine?

The standard reference range for Norepinephrine is Laboratory-specific; typically 15–80 µg/g creatinine in random urine.. Reference ranges vary by laboratory and assay platform — interpret in context of the issuing laboratory's stated range.

Which tests measure Norepinephrine?

Norepinephrine is measured in 3 tests on BiomarkersLabs.com, including Comprehensive Neurotransmitter Add-On - Random, Comprehensive Neurotransmitter Profile - 24 hr, Dried Urine LCMS Neurotransmitters and Diurnal Hormones I.

Biomarker Reference · NE

What does the Norepinephrine test measure?

Norepinephrine (NE) is a clinical biomarker used in neurological-mental-health assessment. Norepinephrine is synthesised from dopamine by dopamine beta-hydroxylase in sympathetic neurons and the adrenal medulla. It is measured in 3 laboratory tests on BiomarkersLabs.com.

Reference Range: Laboratory-specific; typically 15–80 µg/g creatinine in random urine.
Units: µg/g creatinine, nmol/mmol creatinine, µg/24 hr, nmol/24 hr, ng/mg creatinine, μg/g creatinine
Measured In: 3 tests
Category: Neurological

Functional medicine optimalThere is no validated optimal range for assessing anxiety, attention, or mood; interpretation should focus on excluding neuroendocrine tumours and assessing overall sympathetic tone in the clinical context.

What is Norepinephrine?

Norepinephrine is synthesised from dopamine by dopamine beta-hydroxylase in sympathetic neurons and the adrenal medulla. It is the principal sympathetic postganglionic neurotransmitter, regulating arousal, attention, vigilance, and the cardiovascular stress response. Urine norepinephrine reflects sympathetic nervous system activity and adrenal catecholamine output; its metabolite normetanephrine is preferred for phaeochromocytoma screening.

Why is Norepinephrine measured?

Urine norepinephrine provides a functional snapshot of sympathetic tone. Chronic elevation is seen in sustained stress, anxiety disorders, and catecholamine-secreting tumours; low levels may accompany autonomic dysfunction or adrenal insufficiency. In functional neurotransmitter testing it is interpreted alongside dopamine and epinephrine to map the stress–arousal–motivation axis.

Reference ranges

Standard reference: Laboratory-specific; typically 15–80 µg/g creatinine in random urine.
Functional medicine optimal: There is no validated optimal range for assessing anxiety, attention, or mood; interpretation should focus on excluding neuroendocrine tumours and assessing overall sympathetic tone in the clinical context.
Units: µg/g creatinine, nmol/mmol creatinine, µg/24 hr, nmol/24 hr, ng/mg creatinine, μg/g creatinine

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.

Tests that measure Norepinephrine

3 tests on BiomarkersLabs.com include this biomarker.

BML-NMH-003Comprehensive

Comprehensive Neurotransmitter Add-On - Random

Norepinephrine reference range in this test: Laboratory-specific; typically 15–80 µg/g creatinine in random urine.

BML-NMH-004Comprehensive

Comprehensive Neurotransmitter Profile - 24 hr

Norepinephrine reference range in this test: Laboratory-specific; typically 15–80 µg/24 hr in adults.

BML-NMH-007Comprehensive

Dried Urine LCMS Neurotransmitters and Diurnal Hormones I

Norepinephrine reference range in this test: Method- and laboratory-specific.

Related clinical conditions

Related Biomarkers

Frequently measured alongside

Serotonin5-HT4 tests DopamineDA4 tests EpinephrineEpi3 tests Gamma-Aminobutyric AcidGABA4 tests GlutamateGlu4 tests GlycineGly3 tests HistamineHis3 tests Dopamine to Norepinephrine RatioDA:NE1 test

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