Biomarker Reference · His
Histamine (His) is a clinical biomarker used in neurological-mental-health assessment. Histamine is synthesised from histidine by histidine decarboxylase and is stored in mast cells and basophils. It is measured in 3 laboratory tests on BiomarkersLabs.com.
Histamine is synthesised from histidine by histidine decarboxylase and is stored in mast cells and basophils. It mediates allergic and inflammatory responses and acts as a neurotransmitter in the hypothalamus and other brain regions. Urinary histamine predominantly reflects peripheral mast-cell and gut activity, not central histaminergic neurotransmission.
Urinary histamine is ordered to investigate mast cell activation, histamine intolerance, and allergic burden in functional and allergy-focused practices. Elevated levels suggest mast-cell degranulation or impaired degradation; normal or low values do not exclude intolerance, as tissue and plasma compartments may not equilibrate with urine.
Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.
3 tests on BiomarkersLabs.com include this biomarker.
Histamine reference range in this test: Laboratory-specific; typically 10–100 µg/g creatinine in random urine.
Histamine reference range in this test: Laboratory-specific; typically 10–100 µg/24 hr in adults.
Histamine reference range in this test: Laboratory-specific; typically 10–200 µg/g creatinine for random urine.
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