What does the DunedinPACE (Pace of Aging Epigenetic Measure) test measure?

Why is DunedinPACE (Pace of Aging Epigenetic Measure) measured?

DunedinPACE is increasingly used in longevity clinical practice as the most intervention-sensitive epigenetic ageing metric available, with published studies demonstrating response to caloric restriction, exercise, and other longevity interventions within months — a time frame shorter than that typically required for age-point clocks to show meaningful change. A DunedinPACE of 1.20 means a patient is biologically ageing at 1.20 years per chronological year — 20% faster than average — while 0.80 means 20% slower. Serial monitoring of DunedinPACE allows practitioners to assess whether interventions are meaningfully slowing the pace of ageing in an individual patient.

Reference ranges

Standard reference

Population average: 1.00 (aging at 1 biological year per chronological year). <1.00 indicates slower-than-average biological ageing; >1.00 indicates faster-than-average biological ageing. # REVIEWER FLAG: Confirm TruDiagnostic's DunedinPACE reporting format and whether they report the original DunedinPACE or the updated DunedinPoAm version. Confirm whether TruDiagnostic's population reference is calibrated to a specific demographic dataset.

Functional medicine optimal

DunedinPACE ≤ 0.80 (longevity medicine ambitious optimal); DunedinPACE ≤ 1.00 (population-average parity target as a minimum). # REVIEWER FLAG: Optimal DunedinPACE targets not standardised — reviewer to confirm framing.

Units

Biological years per chronological year (rate)

Reference ranges vary by laboratory and assay platform. Interpret in context of the issuing laboratory's stated range.